Antiplatelet Drugs Prevent The Formation Of Blood Clots As They Alter Platelet Activation And Aggregation In Response To Endothelial Injury

Antiplatelet Drugs
Antiplatelet Drugs 

Platelets are blood cells that clump together to form a blood clot in case of an injury or cut. They also clump together inside a blood vessel that is damaged or has a buildup of plaque. Blood clots can lead to a heart attack or stroke. Antiplatelet Drugs help to prevent blood clots from forming. They are often prescribed after a heart attack or in case of a disease that increases the risk of having blood clots.

A doctor may prescribe aspirin, clopidogrel, prasugrel or ticagrelor to stop blood clots from forming. Medication for treating an existing heart condition or other illness while taking drugs can also be prescribed. These medications are called concomitant therapies. They work differently and are given at different times during the day. Aspirin and warfarin are often prescribed together, as they act on different parts of the clotting process.

Aspirin reduces the risk of having another heart attack. Antiplatelet Drugs can cause unwanted side effects, such as a sore stomach or bleeding problems. A doctor should be informed in case of any side effects, especially if they are severe. Antiplatelet medicines are usually taken as pills that can be swallowed. They can also be given in a vein, if there is trouble swallowing tablets.

Drugs alter platelet activation and aggregation in response to endothelial injury, a crucial step in arterial thrombosis. Oral medications are broadly classified as irreversible cyclooxygenase inhibitors, ADP receptor inhibitors, adenosine reuptake inhibitors, glycoprotein IIb/IIIa platelet inhibitors, or phosphodiesterase inhibitors. The latter two agents inhibit the breakdown of cyclic AMP on platelets to reduce cytoplasmic second messengers that stimulate thromboxane release.

The Antiplatelet Drugs Market is anticipated to reach US$ 2,153.4 million in 2022 and is predicted to grow at a CAGR of 7.8% from 2022 to 2030.

Glycoprotein IIb/IIIa platelet inhibitors prevent the binding of fibrinogen and von Willebrand factor to the platelet glycoprotein IIb/IIIa receptor on activated platelets, thereby decreasing platelet aggregation and clot formation. These drugs are commonly used in ACS patients who undergo PCI.

A new class of drugs, called direct thrombin inhibitors, directly bind to and block the action of thrombin without the use of an antiplatelet agent. Examples of these drugs are recombinant hirudins (bivalirudin, argatroban), dabigatran (Dabigatran) and apixaban (Edoxaban). Antiplatelet therapy can be disrupted by major bleeding in patients on these medications. In most cases, resumption of antiplatelet therapy is not recommended after major bleeding.

Bayer’s oral Factor Xia inhibitor Asundexian, gained Fast Track designation from the the United States Food and Drug Administration in February 20222. It is an anticoagulant used for treating arterial and venous thrombosis.

Comments

Post a Comment

Popular posts from this blog

Biopreservation Have Become Important Tool For Bioengineering, Computer Sciences, Molecular Biology, And Cellular Biology

Image
Biopreservation Biopreservation is an increasingly important area of science, spanning fields as diverse as cryobiology, bioengineering, computer sciences, molecular biology, and cellular biology. The field is expanding rapidly in response to new challenges, including stem cell research, personalized medicine, and cancer research. In order to optimize the process for each particular application, it is crucial to evaluate the benefits and drawbacks of various techniques. The processes use natural macrobiotics to enhance food safety and preserve their quality and nutritional content. The most common biopreservatives are produced by lactic acid bacteria, which are antagonistic to most foodborne pathogens. Lactic acid bacteria are able to produce a variety of antimicrobial compounds, including acetic acid and hydrogen peroxide. In addition, some lactic acid bacteria can also produce nisin, a highly effective preservative. Another form of Biopreservation is inoculation, in which natural b...
Read more

Gynecological Cancer Drugs Are Of Different Types and Are Used Depending On the Specific Needs of the Patient

Image
Gynecological Cancer Drugs Recognizing the signs of gynecological cancer is crucial since the symptoms are often vague. It is hence important for women to know what they should be looking for and how to identify the signs of gynecological cancer. The CDC has developed a symptom diary for women to keep track of their symptoms. Women with unusual symptoms should also contact their healthcare provider right away. However, in some cases, women may experience a sudden onset of these symptoms. There are different types of Gynecological Cancer Drugs used in the treatments such as chemotherapy. Several types of immunotherapy are now being studied to combat cancer. These therapies are based on the immune system and use the patient's own immune system to fight the disease. Although not approved for all types of cancer, they are being tested on a larger scale. Moreover, these therapies are still in their early stages, so it may take several years before they can be applied to specific cancer...
Read more

Cancer Biologics Is A Biological Therapy That Is Made By Reproducing, Or Growing, Cells In A Carefully Controlled Laboratory Setting

Image
Cancer Biologics Cancer Biologics are drugs that use a patient’s body to fight the disease or to reduce side effects from other treatments such as chemotherapy and radiation. The word biologics refers to substances made from living organisms or their products and used as diagnostic, preventive or therapeutic agents. Some of the ways these drugs work are to help the immune system recognize and fight cancer cells or to suppress the immune system’s inflammatory response that can cause serious side effects. As more biologic drugs are approved by regulatory bodies for the treatment of cancer, the worldwide Cancer Biologics Market is anticipated to develop significantly over the course of the projected period. Biological therapy may also make it easier for the immune system to kill cancer cells by blocking signals that cancer cells send out to hide from the body’s normal defenses. This type of therapy is a highly active area of cancer research. There are many different types of cancer trea...
Read more