Hepatic Encephalopathy Is A Serious Condition That Develops In People With Liver Disease Like Acute Liver Failure, Cirrhosis

Hepatic Encephalopathy

Hepatic Encephalopathy is a condition that occurs when the liver cannot remove enough toxins from the blood. It can happen in people with cirrhosis, acute liver failure, or chronic liver disease.

HE is a brain disorder that occurs when the liver can't filter out toxins that build up in the blood. The toxins can affect the brain's ability to think clearly. It's usually caused by long-term diseases of the liver, such as chronic hepatitis or cirrhosis.

The symptoms of HE begin when the liver is damaged from a disease, such as chronic hepatitis, Reye's syndrome or cirrhosis. The damaged liver can't process toxins properly. These toxins can then build up in the blood and travel to the brain, where they cause symptoms.

Throughout the projected period, the worldwide Hepatic Encephalopathy Market is anticipated to grow at a CAGR of 5.3%, reaching an estimated value of US$ 355.4 Mn in 2020. (2020-2027).

Symptoms may be severe enough to require treatment. These symptoms include drowsiness, confusion and poor coordination. It can also affect the person’s thinking, memory and ability to make decisions. In severe cases, it can lead to loss of consciousness and coma.

Hepatic Encephalopathy is a serious condition that can lead to death if left untreated. It is more common in people with liver cirrhosis than it is in the general population.

HE happens when the liver can't filter out toxins that are sent from the intestine into the bloodstream. These toxins may be produced naturally in the body or from medicines. In the normal liver, toxins are removed from the bloodstream before they can damage brain cells.

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Doctors will perform a physical examination and order tests to find out what's causing the symptoms. Patients’ blood will be tested checking for ammonia levels. These tests can show if there are more toxins in the blood than normal.

Other tests can tell what's causing these symptoms. A health care provider may also order x-rays to see if there's any damage in the brain. Hepatic Encephalopathy can be difficult to diagnose, and it can mimic other disorders. It's important to talk to a doctor about all the symptoms and ask what the best way to treat them is.

HE is most common in people with liver disease. Other conditions, such as certain infections and bleeding in the digestive tract, can trigger HE.

The most important way to prevent Hepatic Encephalopathy is to treat the underlying liver condition that caused it. Eating well and getting enough sleep, keeping blood levels of sodium, potassium and other nutrients balanced can help prevent HE.

A Karolinska Development portfolio firm Umecrine Cognition AB, published their findings for a phase IIa clinical study of golexanolone in April 2020. They are evaluating the effects of this therapeutic candidate on patients who are at the risk of developing HE.