Continuous Renal Replacement Therapy CRRT Is More Efficient Than Intermittent Hemodialysis In Solute Clearance And Better Hemodynamic Tolerability

Continuous Renal Replacement Therapy
Continuous Renal Replacement Therapy 

Continuous Renal Replacement Therapy (CRRT) is a type of dialysis treatment that is used to treat critically ill patients with renal failure. CRRT involves the use of an artificial kidney, which removes excess fluid from the body. A specialized machine takes blood from the patient to the kidney, where waste products are filtered. The kidney is then able to start producing urine again.

CRRT is a valuable therapy for the care of critically ill patients with acute renal failure. The best method for assessing the dose of a treatment is the clearance of marker substances. These include plasma and large mole weight substances. CRRT also has better clearance of these solutes, as it has been shown that small mole weight solutes are cleared at a slower rate.

Continuous Renal Replacement Therapy is most often used in critically ill surgical patients with acute kidney injury. This condition is most commonly caused by trauma, as it can also occur from ischemic injury or hemorrhagic shock. During acute kidney injury, the body accumulates extra fluid that can cause swelling and heart problems. Excess fluid in the blood can cause infections.

CRRT provides a more rapid and effective means of solute removal than intermittent hemodialysis, a technique that uses a filter to purify blood. It can also be used in other conditions, such as cardiac failure and tumor lysis syndrome. However, it is unclear whether it has advantages over intermittent therapies.

The prevalence of chronic kidney disease, which is a major risk factor for diabetes, hypertension, cardiovascular disease, and the inflammatory kidney disease glomerulonephritis, is one of the main drivers driving the expansion of the Continuous Renal Replacement Therapy Market.

There are no specific recommendations for the use of diuretics during CRRT, whereas the presence of an increase in urination is a good indication that the kidneys are trying to recover. If a patient produces more than 500 ml to 1,000 ml of urine daily, they can be tested to see if the urine is filtering out toxins.

Using a computer model, Clark et al compared the solute clearance in intermittent hemodialysis and Continuous Renal Replacement Therapy in 20 critically ill patients. Several theoretical advantages of CRRT over intermittent blood purification techniques have been demonstrated, such as improved hemodynamic tolerability and better control of intravascular volume.

Fresenius Medical Care gained Emergency Use Authorization from the US FDA for multiFiltrate PRO System and multiBic Solutions in April 2020. This system is used for treating patients in acute care during the pandemic.

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